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Leukoencephalopathy with vanishing white matter (VWM disease) is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor eIF2B: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5.
Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor.It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNA i Met to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha (also called subunit 1, EIF2S1), a beta (subunit 2, EIF2S2), and a gamma (subunit 3, EIF2S3) subunit.
Bacterial initiation factor-2 is a bacterial initiation factor. [1] IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNA f binds to the IF2 then IF2 transfers the tRNA into the partial P site.
The initiation factor interacts with the eIF1 and eIF5 factors used for scanning and selection of the start codons. This can create changes in the selection of the factors, binding to different codons. [8] Another important eukaryotic initiation factor, eIF2, binds the tRNA containing methionine to the P site of the small ribosome. The P site ...
The IF2 initiation factor is a crucial component in the process of protein synthesis. The largest among the three indispensable translation initiation factors is IF-2, which possesses a molecular mass of 97 kDa. [17] [18] The protein has many domains, including an N-terminal domain, a GTPase domain, a linker region, C1, C2, and C-terminal domains.
Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic translation. These proteins help stabilize the formation of ribosomal preinitiation complexes around the start codon and are an important input for post-transcription gene regulation .
217715 Ensembl ENSG00000119718 ENSMUSG00000004788 UniProt P49770 Q99LD9 RefSeq (mRNA) NM_014239 NM_145445 RefSeq (protein) NP_055054 NP_663420 Location (UCSC) Chr 14: 75 – 75.01 Mb Chr 12: 85.27 – 85.27 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene. Function Eukaryotic ...
Eukaryotic translation initiation factor 2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β, this article), and gamma (γ), with the protein encoded by this gene representing the beta subunit.
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