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High levels of ALP may indicate liver disease or certain bone disorders, but an ALP test alone cannot diagnose a condition. There are two main types of alkaline phosphatase (ALP) blood tests: a general ALP (the more common test) and an ALP isoenzyme test.
Elevated alkaline phosphatase levels can be caused by conditions such as: Blocked bile ducts; Liver cancer; Cirrhosis; Hepatitis; Narrowing of the bile ducts; Mononucleosis
Causes of an elevated alkaline phosphatase. * The alkaline phosphatase value may vary and be <4 times the upper limit of normal at times (eg, early in the disease process). ¶ May cause an isolated elevation in hepatic alkaline phosphatase if partial obstruction.
The ALP level reference range for adults aged 18 years and older is 30–130 IU/l, according to the NHS. Therefore, some healthcare professionals may consider ALP levels over 130 IU/l as...
High alkaline phosphatase levels from your liver may be a sign of: Blockages in your bile ducts; Cirrhosis; Hepatitis; Mononucleosis, which can sometimes cause swelling in the liver; If alkaline phosphatase levels are high and the results of liver tests are normal, the problem may be a bone disorder, such as Paget's disease of bone. This ...
If alkaline phosphatase is raised in an asymptomatic patient and serum bilirubin, liver transaminases, creatinine, adjusted calcium, thyroid function, and blood count are normal: Consider growth spurts in adolescents, pregnancy in women, drugs, and age related increases.
Elevated bone ALP levels can be observed in cases of bone metastasis, Paget disease, osteogenic sarcoma, healing fractures, hyperparathyroidism, hyperthyroidism, and osteomalacia. Elevated intestinal fraction of ALP often occurs after a fatty meal and can be hereditary; however, it typically does not necessitate further evaluation. [55]