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Interferon beta-1b is a cytokine in the interferon family used to treat the relapsing-remitting and secondary-progressive forms of multiple sclerosis (MS). It is approved for use after the first MS event. Closely related is interferon beta 1a, also indicated for MS, with a very similar drug profile.
In 1993, interferon beta-1b was the first drug to ever be approved for MS, being soon followed by interferon beta-1a and glatiramer acetate. [ 25 ] Interferon beta-1a is injected either weekly ( intramuscular injection ) or three times a week ( subcutaneous injection ) depending on commercial formulations, [ 26 ] [ 27 ] while interferon beta-1b ...
Interferon beta-1a (also interferon beta 1-alpha) is a cytokine in the interferon family used to treat multiple sclerosis (MS). [5] It is produced by mammalian cells, while interferon beta-1b is produced in modified E. coli. [6] Some research indicates that interferon injections may result in an 18–38% reduction in the rate of MS relapses. [7]
As of 2016, there are 10 active principles approved which are: Two interferons (interferon beta-1a and interferon beta-1b), glatiramer acetate, mitoxantrone, fingolimod, teriflunomide, [2] dimethyl fumarate [3] and finally three monoclonal antibodies (natalizumab, alemtuzumab [16] and since May 2016, daclizumab [29] [30])
Interferon beta-1a and interferon beta-1b are used to treat and control multiple sclerosis, an autoimmune disorder. This treatment may help in reducing attacks in relapsing-remitting multiple sclerosis [ 43 ] and slowing disease progression and activity in secondary progressive multiple sclerosis.
Natalizumab and interferon beta-1a may reduce relapses compared to both placebo and interferon beta-1a (Avonex) while Interferon beta-1b , glatiramer acetate, and mitoxantrone may also prevent relapses. [146] Evidence on relative effectiveness in reducing disability progression is unclear. [146]
Interferon beta is a protein that in humans is encoded by the IFNB1 gene. [5] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties. Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...
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