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One of the advantages of linezolid is that it has an absolute oral bioavailability of 100% due to its ... are reached one to two hours after ... route better suited ...
Therefore, a drug given by the intravenous route will have an absolute bioavailability of 100% (f = 1), whereas drugs given by other routes usually have an absolute bioavailability of less than one. If we compare the two different dosage forms having same active ingredients and compare the two drug bioavailability is called comparative ...
Therefore, if a drug has a bioavailability of 0.8 (or 80%) and it is administered in a dose of 100 mg, the equation will demonstrate the following: De = 0.8 × 100 mg = 80 mg. That is the 100 mg administered represents a blood plasma concentration of 80 mg that has the capacity to have a pharmaceutical effect.
They also have essentially 100% bioavailability and can be used for drugs that are poorly absorbed or ineffective when they are given orally. [25] Some medications, such as certain antipsychotics, can be administered as long-acting intramuscular injections. [37] Ongoing IV infusions can be used to deliver continuous medication or fluids. [38]
[2] [27] In addition, while a 60 mg dose has no effect on testosterone levels in men, this dose does measurably increase testosterone levels in prepubertal boys and women. [27] The oral bioavailability of testosterone in young women after a single 25 mg dose was found to be 3.6 ± 2.5%. [ 29 ]
The oral bioavailability of megestrol acetate is approximately 100%. [2] After a single low oral dose of 4 mg megestrol acetate, peak serum concentrations of megestrol acetate were about 7 ng/dL (18 nmol/L) and occurred after 3 hours. [2]
Absorption is the journey of a drug travelling from the site of administration to the site of action. [1] [2]The drug travels by some route of administration (oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution). [3]
Route Dose Bioavailability ... T 1/2 (hours) Time to peak effect (minutes) Intravenous 30 mg 100% 108 22 6 9.1 0.8 15 Oral 30 mg 67% 94.1 216 9.1 18 2 Smoking 30 mg