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  2. Biologics Price Competition and Innovation Act of 2009

    en.wikipedia.org/wiki/Biologics_Price...

    The Biologics Price Competition and Innovation Act of 2009 (BPCI Act) amends the Public Health Service Act (PHS Act) to create an abbreviated approval pathway for biological products shown to be biosimilar to, or interchangeable with, an FDA-licensed reference biological product.

  3. Biosimilar - Wikipedia

    en.wikipedia.org/wiki/Biosimilar

    The BPCI Act was an amendment to the Public Health Service Act (PHS Act) to create an abbreviated approval pathway for biological products that are demonstrated to be highly similar (biosimilar) to a Food and Drug Administration (FDA) approved biological product. [134]

  4. US FDA proposes to remove switching study requirement for ...

    www.aol.com/news/us-fda-proposes-remove...

    The FDA has generally recommended switching studies to show evidence of interchangeability of a biosimilar. Regulatory reform is needed so patients can more easily access biosimilars and draw ...

  5. Biopharmaceutical - Wikipedia

    en.wikipedia.org/wiki/Biopharmaceutical

    This pathway is based on a thorough demonstration of comparability of the product to an existing approved product. [21] Within the United States, the Patient Protection and Affordable Care Act of 2010 created an abbreviated approval pathway for biological products shown to be biosimilar to, or interchangeable with, an FDA-licensed reference ...

  6. US FDA approves Amgen's biosimilar to AstraZeneca's rare ...

    www.aol.com/news/us-fda-approves-amgens...

    Amgen's drug will be marketed under the name Bkemv. Biosimilars are close copies of complex biological drugs. In 2022, the company said that Bkemv met the main goal of a late stage study, where ...

  7. US FDA approves two biosimilars for blockbuster eye drug Eylea

    www.aol.com/news/us-fda-approves-two-biosimilars...

    The agency approved Biocon Biologics' Yesafili as well as Samsung Bioepis and Biogen's Opuviz, while also allowing interchangeability, or the drug's substitution with biosimilars without the need ...

  8. Biologics license application - Wikipedia

    en.wikipedia.org/wiki/Biologics_License_Application

    A biologics license application (BLA) is defined by the U.S. Food and Drug Administration (FDA) as follows: The biologics license application is a request for permission to introduce, or deliver for introduction, a biologic product into interstate commerce (21 CFR 601.2). The BLA is regulated under 21 CFR 600 – 680.

  9. Denali Therapeutics Announces U.S. FDA Breakthrough Therapy ...

    lite.aol.com/tech/story/0022/20250108/9328463.htm

    Denali expects to submit a Biologics License Application (BLA) for tividenofusp alfa in early 2025 for regulatory review under the accelerated approval pathway. “FDA Breakthrough Therapy Designation is another significant achievement in the development of tividenofusp alfa, our first Enzyme TransportVehicle™ program, uniquely designed to ...

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