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Nicotine polacrilex is nicotine bound to an ion-exchange resin (polymethacrylic acid, such as Amberlite IRP64, Purolite C115HMR or Doshion P551). [4] It is added to gum and hard lozenges used for nicotine replacement therapy in smoking cessation , such as in the Nicorette range of products.
A nicotine lozenge is a modified-release dosage tablet (usually flavored) that contains a dose of nicotine polacrilex, which dissolves slowly in the mouth to release nicotine over the course of 20 to 30 minutes. Nicotine lozenges are intended to help individuals quit smoking and are generally an over-the-counter medication.
Nicorette is the brand name of a number of products for nicotine replacement therapy (NRT) that contain nicotine polacrilex.Developed in the late 1970s in Sweden by AB Leo [] in the form of a chewing gum, Nicorette was the first nicotine replacement product on the market.
Nicotine lozenges deliver doses as low as 1 mg up to 4 mg. It is not chewed as the gum would be, and dissolves in approximately 30 minutes. [33] This formulation may be preferred by those individuals who do not find gum chewing to be acceptable. Nicotine gum is available in doses of 2 mg and 4 mg.
Nicotine is unusual in comparison to most drugs, as its profile changes from stimulant to sedative with increasing dosages, a phenomenon known as "Nesbitt's paradox" after the doctor who first described it in 1969. [135] [136] At very high doses it dampens neuronal activity. [137] Nicotine induces both behavioral stimulation and anxiety in ...
Nicotine gum is a chewing gum containing a small dose of nicotine polacrilex. [1] It is classified as a short-acting (also called fast-acting) form of NRT because it relieves the cravings and symptoms that occur with smoking cessation more quickly than a long-acting NRT (i.e., the nicotine patch). It can be used alone or in conjunction with ...
Nicotine-only products — Nicotine-containing products that do not contain tobacco, featuring nicotine either extracted from tobacco or non-tobacco nicotine, usually synthetic nicotine. Common nicotine-only products include e-liquid ( aerosolized using an e-cigarette or vape ), nicotine pouches , and various types of nicotine replacement ...
Zyn pouches are sold in round cans containing 15 or 20 pouches depending on the market. Pouches are available in different levels of nicotine strength (such as 3 or 6 milligrams per pouch in the US) and different flavored and unflavored varieties. [17] The pouches contain nicotine extracted from tobacco leaves, and food grade ingredients. [18]
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