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Headache — an often transient side effect that is common to most serotonin reuptake inhibitors and that most often occurs at the beginning of therapy or after a dose escalation.
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant medication of the serotonin–norepinephrine reuptake inhibitor (SNRI) class. [ 6 ] [ 9 ] It is used to treat major depressive disorder , generalized anxiety disorder , panic disorder , and social anxiety disorder . [ 9 ]
The cause of serotonin toxicity or accumulation is an important factor in determining the course of treatment. Serotonin is catabolized by monoamine oxidase A in the presence of oxygen , so if care is taken to prevent an unsafe spike in body temperature or metabolic acidosis, oxygenation will assist in dispatching the excess serotonin.
They can also cause low blood pressure, raising the risk of fainting and falls, the CDC says. Diuretics These medications help reduce the buildup of fluid in the body, the Cleveland Clinic explains.
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Mild symptoms may consist of increased heart rate, fever, shivering, sweating, dilated pupils, myoclonus (intermittent jerking or twitching), as well as hyperreflexia. [119] Concomitant use of SSRIs or SNRIs for depression with a triptan for migraine does not appear to heighten the risk of the serotonin syndrome. [120]
Diuretics, or water pills, can also cause dehydration and mineral imbalances. - Allergy medications: Some over-the-counter antihistamines reduce sweating and can impair temperature regulation.
As of 2001, at least 21 different antidepressants, covering all the major classes, were known to cause discontinuation syndromes. [21] The problem has been poorly studied, and most of the literature has been case reports or small clinical studies ; incidence is hard to determine and controversial.