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H1299, also known as NCI-H1299 [1] [2] or CRL-5803, [3] is a human non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research. [ 4 ] As with other immortalized cell lines, H1299 cells can divide indefinitely.
ATCC or the American Type Culture Collection is a nonprofit organization which collects, stores, and distributes standard reference microorganisms, cell lines and other materials for research and development. Established in 1925 to serve as a national center for depositing and distributing microbiological specimens, ATCC has since grown to ...
Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. This is a list of major breast cancer cell lines that are primarily used in breast cancer ...
Estimates based on screening of leukemia-lymphoma cell lines suggest that about 15% of these cell lines are not representative of what they are usually assumed to be. [2] A project is currently underway to enumerate and rename contaminated cell lines to avoid errors in research caused by misattribution. [3] [4] [a]
Many methods are used to identify cell lines, including isoenzyme analysis, human lymphocyte antigen (HLA) typing, chromosomal analysis, karyotyping, morphology and STR analysis. [35] One significant cell-line cross contaminant is the immortal HeLa cell line. HeLa contamination was first noted in the early 1960s in non-human culture in the USA.
There are several examples of immortalised cell lines, each with different properties. Most immortalised cell lines are classified by the cell type they originated from or are most similar to biologically 3T3 cells – a mouse fibroblast cell line derived from a spontaneous mutation in cultured mouse embryo tissue.
A20 cells, also called ATCC TIB-208, is a cell line originally derived from B-cell lymphoma in an old BALB/c mouse. [1] AT20 cells are BALB/c lymphoma cells derived from spontaneous reticulum cell neoplasm. [2] ATCC TIB-208 cells originated from B-cell lymphoma in the reticulum cell sarcoma of an elderly BALB/c mouse. [3]
MIA PaCa-2 is a human pancreatic cancer cell line used extensively in pancreatic cancer research and therapy development. [1] In 1977, [2] MIA PaCa-2 cells were derived from the carcinoma of a 65-year-old male. [citation needed] The cells exhibit CK5.6, AE1/AE3, E-cadherin, vimentin, chromogranin A, synaptophysin, SSTR2, and NTR1, but not CD56. [1]