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Heartburn is a common symptom of late term pregnancy during which up to 80% of pregnant women have experienced it by the end of their third trimester. [12] Heartburn often indicates the development of gastro-esophageal reflux disease (GERD), where the lower esophageal sphincter relaxes due to elevated progesterone levels causing increased ...
Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. [4]
Whether it is safe for use in pregnancy is unclear. [1] It works by blocking the release of stomach acid. [1] Omeprazole was patented in 1978 and approved for medical use in 1988. [15] [16] It is on the World Health Organization's List of Essential Medicines. [17] It is available as a generic medication. [1]
Use appears to be safe in pregnancy and breastfeeding. [6] How it works is unclear but is believed to involve binding to the ulcer and protecting it from further damage. [3] [6] Sucralfate was approved for medical use in the United States in 1981. [3] It is available as a generic medication.
Use in pregnancy appears to be safe, while safety during breastfeeding is unclear. [3] Esomeprazole is the (S)-(−)-enantiomer (or less specifically the S-isomer) of omeprazole. [11] It works by blocking H + /K +-ATPase in the parietal cells of the stomach. [11] It was patented in 1993 and approved for medical use in 2000. [14]
It appears to be safe during pregnancy but has not been well studied in this group. [8] It is a serotonin 5-HT 3 receptor antagonist. [8] It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause akathisia. [11] Ondansetron was patented in 1984 and approved for medical use in 1990. [12]
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