Search results
Results from the WOW.Com Content Network
Alcohol is also converted into phosphatidylethanol (PEth, an unnatural lipid metabolite) by phospholipase D2. This metabolite competes with PIP 2 agonist sites on lipid-gated ion channels. [28] [29] The result of these direct effects is a wave of further indirect effects involving a variety of other neurotransmitter and neuropeptide systems. [25]
Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma-aminobutyric acid. The ...
A muscarinic acetylcholine receptor agonist, also simply known as a muscarinic agonist or as a muscarinic agent, is an agent that activates the activity of the muscarinic acetylcholine receptor. [1] The muscarinic receptor has different subtypes, labelled M1-M5, allowing for further differentiation.
α 2 agonist: inhibits adenylyl cyclase activity, reduces brainstem vasomotor center-mediated CNS activation; used as antihypertensive, sedative & treatment of opiate dependence and alcohol withdrawal symptoms). Selected examples are: Brimonidine; Clonidine (mixed alpha2-adrenergic and imidazoline-I1 receptor agonist) Dexmedetomidine; Fadolmidine
Genetic variation in this region also displays influence susceptibility to use drugs of abuse, including cocaine and alcohol consumption. [44] Nicotinic receptors containing α 6 or β 3 subunits expressed in brain regions, especially in the ventral tegmental area and substantia nigra , are important for drug behaviors due to their role in ...
For example, the drug pirenzepine is a muscarinic antagonist (decreases the effect of ACh), which is much more potent at M 1 receptors than it is at other subtypes. The acceptance of the various subtypes proceeded in numerical order, therefore, earlier sources may recognize only M 1 and M 2 subtypes, [ citation needed ] while later studies ...
Baclofen is a GABA analogue which acts as a selective agonist of GABA B receptors, and is used as a muscle relaxant. However, it can aggravate absence seizures, and so is not used in epilepsy. gamma-Hydroxybutyrate (GHB) Phenibut; 4-Fluorophenibut; Isovaline; 3-Aminopropylphosphinic acid; Lesogaberan
Beta-2 agonist is a drug that opens the bronchial airways and often helps build muscle. Agonist is often referred to as a drug that stimulates natural processes in the body and beta-2 to a cell receptor. They are clinically used to help asthma patients. Yet, the abuse of beta-3 agonists can be used as an enhancer. Examples of beta-2 agonists ...