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Higher levels of ketones in the urine indicate that the body is using fat as the major source of energy. Ketone bodies that commonly appear in the urine when fats are burned for energy are acetoacetate and beta-hydroxybutyric acid. Acetone is also produced and is expired by the lungs. [1]
When the body relies on fats, rather than carbohydrates, as its main energy source, increased levels of ketones occur in the blood and urine. The presence of detectable levels of ketones in the urine is called ketonuria. Ketones occur in three forms in the body: beta-hydroxybutyrate (BHB), acetone and acetoacetate.
Automatic analysis of urine test strips using automated urine test strip analysers is a well-established practice in modern-day urinalysis. They can measure calcium , blood, glucose, bilirubin, urobilinogen, ketones, leukocytes, creatinine , microalbumin , pH, ascorbic acid and protein.
Reference ranges for urine tests are described below: Measurement Lower limit Upper limit ... Ketones: n/a: 0 / negative [2] Bilirubin: n/a: 0 / negative [2] Blood: n ...
They experience attacks of ketoacidosis during illness, and even when well may have elevated levels of ketone bodies in blood and urine (ketonemia and ketonuria, respectively). Not all people with SCOT deficiency have persistent ketonemia and ketonuria, particularly those with milder defects of enzyme activity.
The concentration of ketone bodies in blood is maintained around 1 mg/dL. Their excretion in urine is very low and undetectable by routine urine tests (Rothera's test). [18] When the rate of synthesis of ketone bodies exceeds the rate of utilization, their concentration in blood increases; this is known as ketonemia.
Ketosis is a metabolic state characterized by elevated levels of ketone bodies in the blood or urine. Physiological ketosis is a normal response to low glucose availability. . In physiological ketosis, ketones in the blood are elevated above baseline levels, but the body's acid–base homeostasis is maintain
DKA results from a shortage of insulin; in response, the body switches to burning fatty acids, which produces acidic ketone bodies. [3] DKA is typically diagnosed when testing finds high blood sugar, low blood pH and keto acids in either the blood or urine. [1] The primary treatment of DKA is with intravenous fluids and insulin. [1]