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Pyramidal cells, or pyramidal neurons, are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala. Pyramidal cells are the primary excitation units of the mammalian prefrontal cortex and the corticospinal tract .
The pyramidal cells in CA3 have a unique type of dendritic spine called a thorny excrescence or thorn, only found in CA3 pyramidal cells and hilar mossy cells. The thorn has a thin single spine with a number of heads. Clusters of thorns sit on a dendrite on a broad stem.
These perisomatic (around the cell body) and basal dendrites project into all cortical layers, but most of their horizontal branches/arbors populate layers V and VI, some reaching down into the white matter. [5] According to one study, Betz cells represent about 10% of the total pyramidal cell population in layer Vb of the human primary motor ...
Of the six layers found within the neocortex, layer I is the most superficial and is composed of Cajal–Retzius cells and pyramidal cells. [8] This layer is unique in the aspect that these cells migrate to the outer edge of the cortex opposed to the migration experienced by the other 5 layers.
Apical dendrites from pyramidal cells in the external granular layer and more prominently the external pyramidal layer project into the molecular layer. [1] There are also in the plexiform layer GABAergic synaptic connections between the apical dendrites of granular cells and the basal dendrites of the tufted cells and mitral cells .
Schaffer collaterals are the axons of pyramidal cells that connect two neurons (CA3 and CA1) and transfer information from CA3 to CA1. [5] [6] The entorhinal cortex sends the main input to the dentate gyrus (perforant pathway). From the granule cells of the dentate gyrus, connections are made to the CA3 regions of the hippocampus via mossy fibers.
A place cell is a kind of pyramidal neuron in the hippocampus that becomes active when an animal enters a particular place in its environment, which is known as the place field. Place cells are thought to act collectively as a cognitive representation of a specific location in space, known as a cognitive map. [1]
The anterior part of the right hippocampus was larger and the posterior part was smaller, compared with sighted individuals. [78] There are several navigational cells in the brain that are either in the hippocampus itself or are strongly connected to it, such as the speed cells present in the medial entorhinal cortex. Together these cells form ...
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