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The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca 2+ ion channel found in neurons. [ 3 ] [ 4 ] The NMDA receptor is one of three types of ionotropic glutamate receptors , the other two being AMPA and kainate receptors .
The name "NMDA receptor" is derived from the ligand N-methyl-D-aspartate (NMDA), which acts as a selective agonist at these receptors. When the NMDA receptor is activated by the binding of two co-agonists, the cation channel opens, allowing Na + and Ca 2+ to flow into the cell, in turn raising the cell's electric potential. Thus, the NMDA ...
14812 Ensembl ENSG00000273079 ENSMUSG00000030209 UniProt Q13224 Q01097 RefSeq (mRNA) NM_000834 NM_008171 NM_001363750 RefSeq (protein) NP_000825 NP_032197 NP_001350679 Location (UCSC) Chr 12: 13.44 – 13.98 Mb Chr 6: 135.69 – 136.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutamate [NMDA] receptor subunit epsilon-2, also known as N -methyl D-aspartate receptor subtype 2B ...
242443 Ensembl ENSG00000198785 ENSMUSG00000039579 UniProt Q8TCU5 A2AIR5 RefSeq (mRNA) NM_133445 NM_001033351 NM_001276355 RefSeq (protein) NP_597702 NP_001028523 NP_001263284 Location (UCSC) Chr 9: 101.57 – 101.74 Mb Chr 4: 49.66 – 49.85 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutamate [NMDA] receptor subunit 3A is a protein that in humans is encoded by the GRIN3A gene ...
Since the block must be removed by outward current flow, NMDA receptors rely on the EPSC produced by AMPA receptors to open. NMDA receptors are permeable to Ca 2+, [22] which is an important cation in the nervous system [23] and has been linked to gene regulation. [24] The flow of Ca 2+ through NMDA receptors is thought to cause both long-term ...
Glutamate [NMDA] receptor subunit zeta-1 is a protein that in humans is encoded by the GRIN1 gene. [5] [6]The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel.
Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene. [5] With 1464 amino acids, the canonical GluN2A subunit isoform is large. GluN2A-short isoforms specific to primates can be produced by alternative splicing and contain 1281 amino acids.
Two molecular mechanisms for synaptic plasticity involve the NMDA and AMPA glutamate receptors. Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca 2+ concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely ...