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Suppression of tumorigenicity 2 [1] is a gene that in humans is located on chromosome 11p14.3-p12. This region (ST2; GeneID: 6761) [ 2 ] on chromosome 11 represents a putative locus that is associated with various forms of cancer.
The suppression of tumorigenicity in these hybrid cells prompted researchers to hypothesize that genes within the normal somatic cell had inhibitory actions to stop tumor growth. [6] This initial hypothesis eventually lead to the discovery of the first classic tumor suppressor gene by Alfred Knudson , known as the Rb gene, which codes for the ...
19143 Ensembl ENSG00000149418 ENSMUSG00000031995 UniProt Q9Y5Y6 P56677 RefSeq (mRNA) NM_021978 NM_011176 RefSeq (protein) NP_068813 NP_035306 Location (UCSC) Chr 11: 130.16 – 130.21 Mb Chr 9: 31 – 31.04 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Suppressor of tumorigenicity 14 protein, also known as matriptase, is a protein that in humans is encoded by the ST14 gene. ST14 ...
Suppression of tumorigenicity 2: encoding protein Suppression of tumorigenicity 2; TAF1D: TATA box binding protein associated factor RNA polymerase 1 subunit D; TALDO1 encoding protein Transaldolase 1; TBRG1: transforming growth factor beta regulator 1; TECTA: tectorin alpha (nonsyndromic deafness) TH: tyrosine hydroxylase
KLF17 suppression promotes tumor cell epithelial-mesenchymal transition (EMT), which leads to metastasis. Transcription factor Id1 is a direct target of KLF17 and mediates its metastatic functions. KLF17 expression is significantly downregulated and Id1 expression is upregulated in breast cancer metastasis.
The first direct evidence for DCC as a tumour suppressor gene was published in 1995. Researchers found that addition of DCC to an immortalized cell line suppressed tumorigenicity rather definitively. [40] However no mechanism for this suppression was obvious, and it took several years to propose one.
23849 Ensembl ENSG00000067082 ENSMUSG00000000078 UniProt Q99612 O08584 Q8BPQ2 RefSeq (mRNA) NM_001008490 NM_001160124 NM_001160125 NM_001300 NM_011803 RefSeq (protein) NP_001153596 NP_001153597 NP_001291 NP_035933 Location (UCSC) Chr 10: 3.78 – 3.79 Mb Chr 13: 5.91 – 5.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Krueppel-like factor 6 is a protein that in humans is encoded ...
The Let-7 microRNA precursor gives rise to let-7, a microRNA (miRNA) involved in control of stem-cell division and differentiation. [1] let-7, short for "lethal-7", was discovered along with the miRNA lin-4 in a study of developmental timing in C. elegans, [2] making these miRNAs the first ever discovered.