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One important note: Excess biotin can also "cause incorrect results in certain laboratory tests that look at thyroid levels and blood markers that can help diagnose heart attacks," says Dr. Castillo.
Smoking: Recent studies [14] suggest that smoking can lead to marginal biotin deficiency because it speeds up biotin catabolism (especially in women). [19] Excessive alcohol consumption [20] (causes a significant reduction in plasma biotin levels) Excessive consumption of antidiuretics or inadequate levels of antidiuretic hormone [21]
Discover what this essential B vitamin can do for your body and whether you need more in your diet.
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Primary biotin deficiency, meaning deficiency as a consequence of too little biotin in the diet, is rare, because biotin is contained in so many foods. Subclinical deficiency can cause mild symptoms, such as hair thinning, brittle fingernails, or skin rash, typically on the face.
Treatment consists of dietary protein restriction, particularly leucine. During acute episodes, glycine is sometimes given, which conjugates with isovalerate forming isovalerylglycine, or carnitine which has a similar effect. [citation needed] Elevated 3-hydroxyisovaleric acid is a clinical biomarker of biotin deficiency.
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The standard treatment regimen calls for 5–10 mg of biotin per day. [ 6 ] Biotinidase deficiency is inherited in an autosomal recessive pattern, which means the defective gene is located on an autosome , and two copies of the defective gene - one from each parent - must be inherited for a person to be affected by the disorder.