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The PFA-100 (Platelet Function Assay [1] or Platelet Function Analyser [2]) is a platelet function analyser that aspirates blood in vitro from a blood specimen into disposable test cartridges through a microscopic aperture cut into a biologically active membrane at the end of a capillary.
Aspirin inhibits platelet function via the AA pathway while clopidogrel inhibits platelet function via the ADP pathway; thus, this test can be used to determine the degree to which a patient is anticoagulated due to either medication. In this assay, a standard TEG is run using patient's whole blood.
The ristocetin-induced platelet aggregation (RIPA) is an ex vivo assay for live platelet function. It measures platelet aggregation with the help of von Willebrand factor (vWF) and exogenous antibiotic ristocetin added in a graded fashion. [ 1 ]
These parameters denote the speed at which a solid clot forms and are primarily influenced by platelet function, but to a certain extent especially fibrinogen and coagulation factors contribute. A prolonged CFT (or a lower alpha-angle) is usually caused by poor platelet function, low platelet count, fibrin polymerization disorders or fibrinogen ...
Multiplate multiple electrode aggregometry (MEA) is a test of platelet function in whole blood. [1] [2] The test can be used to diagnose platelet disorders, [3] [4] [5] monitor antiplatelet therapy, [6] and is also investigated as a potential predictor of transfusion requirements and bleeding risk in cardiac surgery. [7]
The PFA-100 (Platelet Function Assay — 100) is a system for analysing platelet function in which citrated whole blood is aspirated through a disposable cartridge containing an aperture within a membrane coated with either collagen and epinephrine or collagen and ADP. These agonists induce platelet adhesion, activation and aggregation, leading ...
Light transmission aggregometry is widely accepted as the gold standard diagnostic tool for assessing platelet function, and a result of absent aggregation with any agonist except ristocetin is highly specific for Glanzmann's thrombasthenia. [9] Following is a table comparing its result with other platelet aggregation disorders:
Thrombodynamics test. Non-homogenous: realization of the three-dimensional model of the clot growth; Use of platelet free plasma; Record of information about the clot formation as a diagram, giving the possibility to calculate the key parameters of the blood coagulation system; New test, not widely accepted; Overall hemostatic potential (OHP)