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Ectopic calcification is a pathologic deposition of calcium salts in tissues or bone growth in soft tissues.This can be a symptom of hyperphosphatemia.Formation of osseous tissue in soft tissues such as the lungs, eyes, arteries, or other organs is known as ectopic calcification, dystrophic calcification, or ectopic ossification.
PAM may be confined to certain areas or show diffuse distribution through the lungs. [8] Lung biopsy and autopsy specimens demonstrate characteristic intra-alveolar lamellar microliths. [8] [17] Calcium deposits in the alveoli begin in the lower lobes and spread over a period of years throughout the lungs. [5]
Calcification of soft tissue (arteries, cartilage, heart valves, [1] [2] etc.) can be caused by vitamin K 2 deficiency or by poor calcium absorption due to a high calcium/vitamin D ratio. This can occur with or without a mineral imbalance. A common misconception is that calcification is caused by excess amount of calcium in diet. Dietary ...
Calcinosis is the formation of calcium deposits in any soft tissue. [1] It is a rare condition that has many different causes. These range from infection and injury to systemic diseases like kidney failure .
These abnormal calcium deposits often collect metastatically in the body, including throughout the periarticular tissue, subcutaneous tissue, central nervous system, liver, kidneys, adrenal, bones, and lungs. [3] If ingestion of calcium and alkali is continued, neurologic symptoms such as memory loss, personality changes, lethargy, stupor, and ...
Calcium deposits known as limbus sign may be visible in the eyes. [7] Symptoms are more common at high calcium blood values (12.0 mg/dL or 3 mmol/L). [6] Severe hypercalcaemia (above 15–16 mg/dL or 3.75–4 mmol/L) is considered a medical emergency: at these levels, coma and cardiac arrest can result.
In dystrophic calcification, basophilic calcium salt deposits aggregate, first in the mitochondria, then progressively throughout the cell. [citation needed] These calcifications are an indication of previous microscopic cell injury, occurring in areas of cell necrosis when activated phosphatases bind calcium ions to phospholipids in the membrane.
Diagnosis is partly based on signs and symptoms, which may be supported by biopsy. [6] Findings that make it likely include large lymph nodes at the root of the lung on both sides, high blood calcium with a normal parathyroid hormone level, or elevated levels of angiotensin-converting enzyme in the blood. [6]