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Higher than 50% mortality rate within a month [1] [dubious – discuss] Vasodilatory shock , vasogenic shock , or vasoplegic shock is a medical emergency belonging to shock along with cardiogenic shock , septic shock , allergen-induced shock and hypovolemic shock .
Dobutamine is a direct-acting agent whose primary activity results from stimulation of the β 1-adrenoceptors of the heart, increasing contractility and cardiac output. Since it does not act on dopamine receptors to inhibit the release of norepinephrine (another α 1 agonist), dobutamine is less prone to induce hypertension than is dopamine.
Vasoactive drugs are typically administered using a volumetric infusion device (IV pump). This category of drugs require close observation of the patient with near immediate intervention required by the clinicians in charge of the patient's care. Important vasoactive substances are angiotensin-11, endothelin-1, and alpha-adrenergic agonists.
Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. Although α receptors are less sensitive to epinephrine, when activated at pharmacologic doses, they override the vasodilation mediated by β-adrenoreceptors because there are more peripheral α 1 receptors than β ...
Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation , the widening of blood vessels.
alpha-1 receptors. Under NE binding alpha-1 receptors cause vasoconstriction (contraction of the vascular smooth muscle cells decreasing the diameter of the vessels). These receptors are activated in response to shock or low blood pressure as a defensive reaction trying to restore the normal blood pressure.
This area of the skin will become warmer because of vasodilation (loss of vasoconstriction). [5] Depression of the vasomotor center of the brain can cause the loss of vasomotor tone of blood vessels, resulting in massive dilatation of veins. This will result in a condition called as neurogenic shock. [6]
Neurogenic shock is a distributive type of shock resulting in hypotension (low blood pressure), often with bradycardia (slowed heart rate), caused by disruption of autonomic nervous system pathways. [1] It can occur after damage to the central nervous system, such as spinal cord injury and traumatic brain injury.
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