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Inclusion bodies have a non-unit (single) lipid membrane [citation needed].Protein inclusion bodies are classically thought to contain misfolded protein.However, this has been contested, as green fluorescent protein will sometimes fluoresce in inclusion bodies, which indicates some resemblance of the native structure and researchers have recovered folded protein from inclusion bodies.
Pappenheimer bodies (Peripheral Blood / May-Grünwald Giemsa and Prussian blue stain) Pappenheimer bodies are abnormal basophilic granules of iron found inside red blood cells on routine blood stain. [1] They are a type of inclusion body composed of ferritin aggregates, or mitochondria or phagosomes containing aggregated ferritin. They appear ...
Heinz body stain of feline blood, showing three distinct Heinz bodies. Heinz bodies appear as small round inclusions within the red cell body, though they are not visible when stained with Romanowsky dyes. They are visualized more clearly with supravital staining [5] [6] (e.g., with new methylene blue, crystal violet or bromocresol green).
Cabot rings are thin, red-violet staining, threadlike strands in the shape of a loop or figure-8 that are found on rare occasions in red blood cells (erythrocytes). They are believed to be microtubules that are remnants from a mitotic spindle , and their presence indicates an abnormality in the production of red blood cells. [ 1 ]
Conditions that cause rouleaux formation include infections, multiple myeloma, Waldenström's macroglobulinemia, inflammatory and connective tissue disorders, and cancers. It also occurs in diabetes mellitus and is one of the causative factors for microvascular occlusion in diabetic retinopathy.
Acanthocytes, from peripheral blood, under light microscopy. Note the irregularly shaped, non-circular cells in the image. Acanthocyte (from the Greek word ἄκανθα acantha, meaning 'thorn'), in biology and medicine, refers to an abnormal form of red blood cell that has a spiked cell membrane, due to thorny projections.
Histological slide of the human herpes virus-6 showing infected cells, with inclusion bodies in both the nucleus and the cytoplasm. Inclusion bodies were first described in the late 19th and 20th centuries. One of the earliest figures associated with the discovery of inclusion bodies is Fritz Heinrich Jakob Lewy.
These β4-tetramers accumulate in red blood cells and precipitate to form Hb H inclusion bodies. The inclusion bodies in the mature red blood cells are removed by the spleen and this results in an early destruction of these red blood cells. This destruction of red blood cells by the spleen is termed extravascular hemolysis. [4]