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Using a combination of sequencing techniques, researchers from NIAMS and the National Human Genome Research Institute (NHGRI) surveyed the skin microbiome of patients with atopic dermatitis (AD, also called eczema) to understand the genetic diversity of the bacteria present on the skin and how genetic variants may contribute to disease severity.
Psoriasis is an immune-mediated disease, which means that your body’s immune system starts overacting and causing problems. If you have psoriasis, immune cells become active and produce molecules that set off the rapid production of skin cells. This is why skin in people with the disease is inflamed and scaly.
Normally, the immune system works throughout your body to fight off and defend your body from viruses, bacteria, and infection. In people with autoimmune diseases, the immune cells attack the body’s own healthy tissues by mistake. People with vitiligo may be more likely to develop other autoimmune disorders as well.
The musculoskeletal system consists of the body's bones, muscles, tendons, ligaments, joints, & cartilage. Learn about more than 20 muscle & bone diseases. Find diagnosis, treatment, and prevention information on more than 20 different muscle and bone diseases and conditions affecting the musculoskeletal system.
What is ichthyosis? It is a disorder that causes dry, thickened skin that may look similar to fish scales. Learn more about diagnosing & trea
The musculoskeletal system consists of the body's bones, muscles, tendons, ligaments, joints, and cartilage. Skin Diseases Allergies, irritants, genetic makeup, certain diseases, and immune system problems can cause skin conditions.
A fifth type of the disease, epidermolysis bullosa acquisita, is a rare autoimmune disorder that causes the body’s immune system to attack a certain type of collagen in the person’s skin. Sometimes, it happens with another disease such as inflammatory bowel disease. Very rarely, a medication causes the disease.
Pemphigus is an autoimmune disease in which the immune system mistakenly attacks cells in the top layer of the skin (epidermis) and the mucous membranes. People with the disease produce antibodies against desmogleins, proteins that bind skin cells to one another, and less commonly other proteins in the skin.
Discussing Bone, Muscle, Skin, & Autoimmune Diseases: Info for American Indians, Alaska Natives - audio Spotlight on Research | May 25, 2022 Unraveling the Role of the Skin Microbiome in Health and Disease
Many of the genes they have found are important for the functioning of the immune system. People with certain autoimmune diseases, such as psoriasis, thyroid disease, or vitiligo, are more likely to get alopecia areata, as are those with allergic conditions such as hay fever and atopic dermatitis (eczema).