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The Charmin name was first created on April 19, 1928, by the Hoberg Paper Company in Green Bay, Wisconsin. In 1950, Hoberg changed its name to Charmin Paper Company and continued to produce bath tissue, paper napkins, and other paper products. Procter & Gamble (P&G) acquired Charmin Paper Company in 1957. [1]
He made 504 commercials as Mr. Whipple, earning U.S. $300,000 annually while working only 12–16 days a year. [ 2 ] [ 5 ] In an interview with ABC News on April 22, 1983, he mentioned that the first series of commercials for Charmin he appeared in were filmed in, appropriately enough, Flushing, New York City . [ 6 ]
The first Mad Minute record was set by Sergeant Major Jesse Wallingford in 1908, scoring 36 hits on a 48-inch target at 300 yards (4.5 mils / 15.3 moa). [1] Another world record of 38 hits, all within the 24 inch target at 300 yards (2.25 mils / 7.6 moa), is said to have been set in about 1914 by a Sergt.-Instructor Snoxall. [2] '
The table shows that with target factory ammunition the DSR-1 performs in the 0.34 - 0.63 MOA region. Whether the DSR-1 can perform better under ideal environmental conditions with handloads tailored to the particular rifle and/or if the human test shooters were a limiting factor was not tested by Visier magazine. An article on the DSR-1 in the ...
Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin.The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.
Ustekinumab is used to treat psoriasis. [29] This includes psoriatic arthritis when it affects the skin. [31] [29] It is indicated for the treatment of adult and adolescent patients (12 years and older) with moderate to severe plaque psoriasis (Ps) who are candidates for phototherapy or systemic therapy, and adults with active psoriatic arthritis (PsA) alone or in combination with methotrexate.
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