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The nuclear envelope consists of two lipid bilayer membranes: an inner nuclear membrane and an outer nuclear membrane. [4] The space between the membranes is called the perinuclear space. It is usually about 10–50 nm wide. [5] [6] The outer nuclear membrane is continuous with the endoplasmic reticulum membrane. [4]
Tumor cells often show an aberrant nuclear structure, which is used by pathologists in diagnostics. As changes in the nuclear envelope correspond to functional changes in the nucleus, morphological changes in the nucleus may be involved in carcinogenesis. The regulatory functions of inner nuclear membrane proteins strongly suggest this ...
Nucleoporins are a family of proteins which are the constituent building blocks of the nuclear pore complex (NPC). [1] The nuclear pore complex is a massive structure embedded in the nuclear envelope at sites where the inner and outer nuclear membranes fuse, forming a gateway that regulates the flow of macromolecules between the cell nucleus and the cytoplasm.
The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex associated with both inner and outer membranes of the nucleus. It is composed of SUN-domain proteins and KASH-domain proteins. The SUN-domain proteins are membrane-embedded proteins within the inner nuclear membrane (INM).
KASH domains interact with proteins containing SUN domains in the space between the outer and inner nuclear membranes to bridge the nuclear envelope, and may transfer force from the nucleoskeleton to the cytoplasmic cytoskeleton and enable mechanosensory roles in cells.
The TIM/TOM complex is a protein complex in cellular biochemistry which translocates proteins produced from nuclear DNA through the mitochondrial membrane for use in oxidative phosphorylation. In enzymology , the complex is described as an mitochondrial protein-transporting ATPase ( EC 7.4.2.3 ), or more systematically ATP phosphohydrolase ...
67952 Ensembl ENSG00000173726 ENSMUSG00000093904 UniProt Q15388 Q9DCC8 RefSeq (mRNA) NM_014765 NM_024214 RefSeq (protein) NP_055580 NP_055580.1 NP_077176 Location (UCSC) Chr 1: 235.11 – 235.13 Mb Chr 8: 127.66 – 127.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitochondrial import receptor subunit TOM20 homolog is a protein that in humans is encoded by the TOMM20 gene ...
COX4I1 is a nuclear-encoded isoform of cytochrome c oxidase (COX) subunit 4. Cytochrome c oxidase ( complex IV ) is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane , acting as the terminal ...