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Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP 3 or Ins3P or IP 3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP 2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC).
Calcium signaling is the use of calcium ions (Ca 2+) to communicate and drive intracellular processes often as a step in signal transduction. Ca 2+ is important for cellular signalling , for once it enters the cytosol of the cytoplasm it exerts allosteric regulatory effects on many enzymes and proteins .
In biology, the enzyme ITP3K is abbreviated a number of different ways, including 1D-myo-inositol-trisphosphate 3-kinase, ITP3K, ITPK, IP3-kinase, IP3-3-kinase, Ins(1,4,5)P3 3-kinase. In addition the enzyme may be named as the product of one of 3 genes in humans ITPKA , ITPKB , and ITPKC , or one of two in fruit flies, IP3K1 and IP3K2 —a ...
G q/11/14/15 proteins all activate beta-type phospholipase C (PLC-β) to signal through calcium and PKC signaling pathways. [4] PLC-β then cleaves a specific plasma membrane phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP 2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP 3).
IP3 is a secondary messenger that helps to send neuronal signals through the body. The neuronal cells have the calcium-signaling microdomains in the cytoplasm right next to the pre- and post-synaptic calcium channels in the nerve cells. Figure 1 is an example of how Na-K-ATPase forms the calcium-signaling microdomain.
For about 1% of those ages 50 to 79, test results will show a cancer signal was detected, along with the organ or tissue type associated with that specific cancer signal. An estimated 40% of these ...
Calcium imaging is a microscopy technique to optically measure the calcium (Ca 2+) status of an isolated cell, tissue or medium.Calcium imaging takes advantage of calcium indicators, fluorescent molecules that respond to the binding of Ca 2+ ions by fluorescence properties.
3710 16440 Ensembl ENSG00000096433 ENSMUSG00000042644 UniProt Q14573 P70227 RefSeq (mRNA) NM_002224 NM_080553 RefSeq (protein) NP_002215 NP_542120 Location (UCSC) Chr 6: 33.62 – 33.7 Mb Chr 17: 27.28 – 27.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene ...