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[1] [2] In biomedical engineering, sensitivity analysis can be used to determine system dynamics in ODE-based kinetic models. Parameters corresponding to stages of differentiation can be varied to determine which parameter is most influential on cell fate.
A sensitivity analysis method widely used to screen factors in models of large dimensionality is the design proposed by Morris. [3] The Morris method deals efficiently with models containing hundreds of input factors without relying on strict assumptions about the model, such as for instance additivity or monotonicity of the model input-output ...
Sensitivity analysis studies the relationship between the output of a model and its input variables or assumptions. Historically, the need for a role of sensitivity analysis in modelling, and many applications of sensitivity analysis have originated from environmental science and ecology .
Sensitivity analysis is the study of how the uncertainty in the output of a mathematical model or system (numerical or otherwise) can be divided and allocated to different sources of uncertainty in its inputs. [1] [2] This involves estimating sensitivity indices that quantify the influence of an input or group of inputs on the output.
There exist many software tools that can automate sensitivity analysis to various degrees. Here is a non-exhaustive list. Most of these tools have multiple options, including one-at-a-time sensitivity analysis, multidimensional discrete parametric, continuous low-discrepancy distributions, and pareto-front optimization (listed alphabetically):
Fourier amplitude sensitivity testing (FAST) is a variance-based global sensitivity analysis method. The sensitivity value is defined based on conditional variances which indicate the individual or joint effects of the uncertain inputs on the output.
Variance-based sensitivity analysis (often referred to as the Sobol’ method or Sobol’ indices, after Ilya M. Sobol’) is a form of global sensitivity analysis. [1] [2] Working within a probabilistic framework, it decomposes the variance of the output of the model or system into fractions which can be attributed to inputs or sets of inputs.
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