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Celecoxib, sold under the brand name Celebrex among others, is a COX-2 inhibitor and nonsteroidal anti-inflammatory drug (NSAID). [7] It is used to treat the pain and inflammation in osteoarthritis, acute pain in adults, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, painful menstruation, and juvenile rheumatoid arthritis. [7]
Celebrex (and other brand names for celecoxib) was introduced in 1999 and rapidly became the most frequently prescribed new drug in the United States. By October 2000, its US sales exceeded 100 million prescriptions per year for $3 billion, and was still rising. Sales of Celebrex alone reached $3.1 billion in 2001.
The therapeutic recommended dosages were 12.5, 25, and 50 mg with an approximate bioavailability of 93%. [ 12 ] [ 13 ] [ 14 ] Rofecoxib crossed the placenta and blood–brain barrier, [ 12 ] [ 13 ] [ 15 ] and took 1–3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) around 17 hours.
Let's take a look at one popular drug. Celebrex treats rheumatoid arthritis and osteoarthritis -- two common ailments in the elderly. The generic version, Celecoxib, was more than $10 cheaper from ...
As Celebrex is Pfizer's fourth best-selling drug, raking in $2.9 billion in revenue in 2013 and showing stellar growth year over year of 9%, it's understandable if this court decision rattles ...
NSAID identification on label of generic ibuprofen, an over-the-counter non-steroidal anti-inflammatory drug. Non-steroidal anti-inflammatory drugs [1] [3] (NSAID) [1] are members of a therapeutic drug class which reduces pain, [4] decreases inflammation, decreases fever, [1] and prevents blood clots.
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Etodolac is generally avoided during pregnancy and nursing.NSAIDs may cause adverse cardiovascular effects in the fetus during pregnancy. [3]In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.
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