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Frankfurt am Main (/ ˈ f r æ ŋ k f ər t /; German: [ˈfʁaŋkfʊʁt ʔam ˈmaɪn] ⓘ; [5] [6] lit. "Frank ford on the [a] Main") is the most populous city in the German state of Hesse.Its 773,068 inhabitants as of 2022 make it the fifth-most populous city in Germany.