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Guillain–Barré syndrome (also called "GBS") is a rapid-onset muscle weakness caused by the immune system damaging the peripheral nervous system. [3] Typically, both sides of the body are involved, and the initial symptoms are changes in sensation or pain often in the back along with muscle weakness, beginning in the feet and hands, often spreading to the arms and upper body. [3]
Acute motor axonal neuropathy (AMAN) is a variant of Guillain–Barré syndrome. It is characterized by acute paralysis and loss of reflexes without sensory loss. Pathologically, there is motor axonal degeneration with antibody-mediated attacks of motor nerves and nodes of Ranvier. [citation needed]
There is certainly overlap between Guillain–Barré syndrome, Miller Fisher syndrome and Bickerstaff brainstem encephalitis, as well as other conditions associated with anti-ganglioside antibodies such as chronic ophthalmoplegia with anti-GQ1b antibody and the pharyngo-cervico-brachial variant of GBS.
Guillain–Barré syndrome – nerve damage Neuroregeneration in the peripheral nervous system (PNS) occurs to a significant degree. [ 5 ] [ 6 ] After an injury to the axon, peripheral neurons activate a variety of signaling pathways which turn on pro-growth genes, leading to reformation of a functional growth cone and regeneration.
The myoclonic triangle (also known by its eponym Triangle of Guillain-Mollaret or dentato-rubro-olivary pathway) is an important feedback circuit of the brainstem and deep cerebellar nuclei which is responsible for modulating spinal cord motor activity.
The next morning he had generalised aches, the day after sharp abdominal pain and a fever increasingly raged. Bedridden in pain, he gradually lost the ability to move, to the point, 8 days later of just flickering his eyes or twitch his hands. His cognition was not affected. The symptoms all fit with Guillain–Barré syndrome. His minimal ...
Guillain–Barré syndrome, an acute polyneuropathy, a disorder affecting the peripheral nervous system; Triangle of Guillain-Mollaret, the myoclonic triangle, an important feedback circuit of the brainstem
Georges Charles Guillain (French pronunciation:) (3 March 1876 – 29 June 1961) was a French neurologist born in Rouen. Georges Guillain He studied medicine in Rouen and Paris , where he learned clinical education at several hospitals.