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The first commercially sold sodium hyaluronate had been developed by Endre Alexander Balazs under the brand name of Healon, manufactured by Pharmacia AB in Sweden in 1980. In 1986, sodium hyaluronate was used as an intra-articular injection to treat osteoarthritis of the knee with the product Hyalart/Hyalgan by Fidia of Italy. [27]
Perfluorohexyloctane has been available in multiple markets since 2015 under the brand names Evotears and Novatears, [5] and was additionally approved for medical use in the United States in May 2023 under the brand name Miebo. [4] [6] The US Food and Drug Administration (FDA) considers it to be a first-in-class medication. [7]
Sodium hyaluronate, is a linear polysaccharide molecule of sodium glycuronate and N-acetyl glucosamine. [1] It is commercially extracted from rooster combs or produced by bacterial fermentation. [2] Chondroitin sulfate extracted from shark fin cartilage. [2] Hydroxypropyl methylcellulose (Hypromellose) is extracted from wood pulp. [2]
Dry eye syndrome can lead to blurred vision, instability of the tear film, increased risk of damage to the ocular surface such as scarring of the cornea, and changes in the eye including the neurosensory system. [2] [6] Dry eye occurs when either the eye does not produce enough tears or when the tears evaporate too quickly. [2]
Eye drops used in managing glaucoma help the eye's fluid to drain better and decrease the amount of fluid made by the eye which decreases eye pressure. They are classified by their active ingredient and they include: prostaglandin analogs , beta blockers , alpha agonists, and carbonic anhydrase inhibitors .
Artificial tears are lubricating eye drops used to relieve dryness and irritation of the ocular surface. [1] Dry eye syndrome (keratoconjunctivitis sicca) is a common ocular surface disorder and is characterized by disruption of the tear film and increased inflammation.
Figure 1.0 - Basic anatomical features of the human eye. Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. [1]
Nedocromil sodium is a medication considered as mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade , and as an eye drop under the brand name Alocril .
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