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Chloramphenicol may cause bone marrow suppression during treatment; this is a direct toxic effect of the drug on human mitochondria. [23] This effect manifests first as a fall in hemoglobin levels, which occurs quite predictably once a cumulative dose of 20 g has been given.
Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol, and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product and isolated from the soil bacteria Streptomyces venezuelae; [2] however, all amphenicols are now made by chemical ...
Mildred Catherine Rebstock (November 29, 1919 – February 17, 2011) was an American pharmaceutical chemist.She and her team were the first to fully synthesize chloromycetin, also known as chloramphenicol.
Original mapping by John Snow showing the clusters of cholera cases in the London epidemic of 1854, which is a classical case of using human geography. Human geography or anthropogeography is the branch of geography which studies spatial relationships between human communities, cultures, economies, and their interactions with the environment, examples of which include urban sprawl and urban ...
This glossary of geography terms is a list of definitions of terms and concepts used in geography and related fields, including Earth science, oceanography, cartography, and human geography, as well as those describing spatial dimension, topographical features, natural resources, and the collection, analysis, and visualization of geographic ...
Cultural landscape is a term used in the fields of geography, ecology, and heritage studies, to describe a symbiosis of human activity and environment. As defined by the World Heritage Committee , it is the "cultural properties [that] represent the combined works of nature and of man" and falls into three main categories: [ 1 ]
Some settlement sites may go out of use. This location in Estonia was used for human settlement in 2nd half of first millennium and it is considered an archaeological record, that may provide information on how people lived back then. Landscape history studies the form (morphology) of settlements – for example whether they are dispersed or ...
Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Morocco and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia .