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Each year in the United States, according to the Centers for Disease Control and Prevention (CDC), about 735,000 people have a heart attack and 610,000 people die of coronary heart disease (CHD).
The primary sites of end-target organ damage following an increase in arterial stiffness are the heart, the brain (stroke, white matter hyperintensities (WMHs)), the placenta, and the kidneys (age-related loss of kidney function). [21] Firstly, stiffened arteries compromise the Windkessel effect of the arteries. [22]
Clogged arteries can be a significant factor in severe heart conditions.
Women, diabetic individuals, and elderly individuals are more likely to present with atypical symptoms other than chest pain. [8] Women may present with back pain, shortness of breath, heartburn, nausea, and vomiting. [19] Heart disease in women goes undetected prior to a major cardiac event in up to 60% of cases. [19]
Coronary artery disease is the leading cause of death for both males and females and accounts for approximately 600,000 deaths in the United States every year. [139] According to present trends in the United States, half of healthy 40-year-old males will develop CAD in the future, and one in three healthy 40-year-old females. [140]
About 30% of people have atypical symptoms. [8] Women more often present without chest pain and instead have neck pain, arm pain or feel tired. [11] Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. [12] An MI may cause heart failure, an irregular heartbeat, cardiogenic shock or cardiac arrest. [3] [4]
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