Ads
related to: 5 htp or l tryptophan for depression
Search results
Results from the WOW.Com Content Network
5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
Oxitriptan, also known as L-5-hydroxytryptophan (5-HTP) and sold under various brand names, is a medication and over-the-counter dietary supplement used in the treatment of depression and for other indications.
In humans, the stimulation of serotonin production by administration of tryptophan has an antidepressant effect [3] [4] and inhibition of tryptophan hydroxylase (e.g. by p-Chlorophenylalanine) may precipitate depression. [5] The activity of tryptophan hydroxylase (i.e. the rate at which it converts L-tryptophan into the serotonin precursor L-5 ...
Research suggests that rhodiola rosea may reduce stress, as well as depression and anxiety symptoms. 5-HTP, also known as 5-hydroxytryptophan, has been found to increase serotonin levels in the brain.
The use of 5-HTP instead of tryptophan bypasses the conversion of tryptophan into 5-HTP by the enzyme tryptophan hydroxylase, which is the rate-limiting step in the synthesis of serotonin, and 5-HTP easily crosses the blood–brain barrier unlike tryptophan, which requires a transporter. [114]
The authors included only studies of a high rigor and included both 5-HTP and tryptophan in their review because of the limited data on either. Of 108 studies of 5-HTP and tryptophan on depression published between 1966 and 2000, only two met the authors' quality standards for inclusion, totaling 64 study participants.
Ads
related to: 5 htp or l tryptophan for depression