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Hydroxyzine works by blocking the effects of histamine. [9] It is a first-generation antihistamine in the piperazine family of chemicals. [8] [4] Common side effects include sleepiness, headache, and dry mouth. [8] [9] Serious side effects may include QT prolongation. [9] It is unclear if use during pregnancy or breastfeeding is safe. [8]
It is a potent delirogenic drug in the elderly, particularly in the elderly in cognitive decline (suffering from diagnosed, or in many cases undiagnosed, Alzheimer's disease.) It is not a safe drug for this reason, particularly in combination with opiates in an elderly patient, where the incidence of resulting delirium is very high.
Meclizine, sold under the brand name Bonine, among others, is an antihistamine used to treat motion sickness and dizziness (). [3] It is taken by mouth. [3] Effects generally begin in an hour and last for up to a day.
Vistaril (hydroxyzine) – an antihistamine for the treatment of itches and irritations, an antiemetic, as a weak analgesic, an opioid potentiator, and as an anxiolytic; Vyvanse (lisdexamfetamine) – a pro-drug stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo
It was a combination of theophylline, ephedra, [1] and hydroxyzine, and taken by mouth. [ 2 ] [ 3 ] It is no longer manufactured in the US due to approval of ephedra being withdrawn by the FDA . [ citation needed ]
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A 10 mg dose of cetirizine equals about a 30 mg dose of hydroxyzine in terms of peripheral antihistamine effect.) [36] PET studies with antihistamines have found that brain H 1 receptor occupancy of more than 50% is associated with a high prevalence of somnolence and cognitive decline, whereas brain H 1 receptor occupancy of less than 20% is ...
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