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Use of nasal decongestants (e.g., oxymetazoline) for more than three days leads to tachyphylaxis of response and rebound congestion, caused by alpha-adrenergic receptor downregulation and desensitization. The mechanism may specifically include receptor internalisation and resistance to endogenous vasoconstrictors causing worsening in symptoms ...
Guidelines on the choice of agents and how best to step up treatment for various subgroups in hypertension (high blood pressure) have changed over time and differ between countries. A Comparison of International Guidelines on Goal Blood Pressure and Initial Therapy for Adults With Hypertension (adapted from JNC 8 guidelines [ 1 ] )
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology , drug desensitization refers to two related concepts. First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its ...
Homologous desensitization also occurs with cytokine and other types of receptors, such as those of the epidermal growth factor receptor type, but in these cases desensitization is mediated by other types of receptor kinases. [2] Homologous desensitization serves to limit or restrain a cell's responses to stimuli.
A diagram explaining factors affecting arterial pressure. Pathophysiology is a study which explains the function of the body as it relates to diseases and conditions. The pathophysiology of hypertension is an area which attempts to explain mechanistically the causes of hypertension, which is a chronic disease characterized by elevation of blood pressure.
A new study compares the benefits and risks of taking GLP-1 medications for weight loss, including risks of dementia, addiction, heart disease, and gastrointestinal problems, among others.
Anderson said that replay assist can be used only if there is no contact to the helmet; since Mahomes' helmet was hit, the officials could not use replay assist to confirm if the contact was forcible.
Homologous desensitization occurs when a receptor decreases its response to an agonist at high concentration. [1] It is a process through which, after prolonged agonist exposure, the receptor is uncoupled from its signaling cascade and thus the cellular effect of receptor activation is attenuated.