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Dacryocystitis is an infection of the lacrimal sac, secondary to obstruction of the nasolacrimal duct at the junction of the lacrimal sac. [1] The term derives from Greek dákryon 'tear' cysta 'sac' and -itis 'inflammation'. [2] It causes pain, redness, and swelling over the inner aspect of the lower eyelid and epiphora.
Involutional stenosis is probably the most common cause of nasolacrimal duct obstruction in older people. It affects women twice as frequently as men. Although the inciting event in this process is unknown, clinicopathologic study suggests that compression of the lumen of the nasolacrimal duct is caused by inflammatory infiltrates and edema.
The canal containing the duct is called the nasolacrimal canal. It is formed by indentations in the inferior nasal conchae , maxilla and lacrimal bone . The canal drains into the nasal cavity through the anterior portion of the inferior meatus , which is between the inferior concha and the floor of the nasal cavity.
The lacrimal sac or lachrymal sac [1] is the upper dilated end of the nasolacrimal duct, [2] and is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla. It connects the lacrimal canaliculi , which drain tears from the eye's surface, and the nasolacrimal duct , which conveys this fluid into the nasal cavity. [ 3 ]
Lacrimal gland involvement may cause swelling of the upper eyelid, or proptosis if there is severe swelling. Other orbital masses or inflammation can result in visual disturbance (blurred vision, double vision, visual field impairment), restricted eye movements, pain or discomfort, numbness in the distribution of the supraorbital and/or ...
Muscle biopsy may display several common findings including inflammatory cells invading muscle cells, vacuolar degeneration, and inclusion bodies of aggregations of multiple proteins. [27] sIBM is a challenge to the pathologist and even with a biopsy, diagnosis can be ambiguous. [28]
Sometimes they report weakness or decreased range of motion. The physician examines the knee in full extension, looking for tenderness in the medial knee joint and across the proximal, medial tibial region, and feels for tenderness along the medial tendons of the pes anserine when the knee is flexed at 90 degrees. [citation needed]
Chronic systemic inflammation is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.It can contribute to the development or progression of certain conditions such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease, autoimmune and neurodegenerative ...