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Arachnoid granulations (also arachnoid villi, and pacchionian granulations or bodies) are small outpouchings of the arachnoid mater and subarachnoid space into the dural venous sinuses of the brain. The granulations are thought to mediate the draining of cerebrospinal fluid (CSF) from the subarachnoid space into the venous system .
The arachnoid mater is named after the Greek word arachne ("spider"), the suffix -oid ("in the image of"), and the Latin word mater ("mother"), because of the fine spider-web–like appearance of the delicate fibres of the arachnoid (arachnoid trabeculae) which extend down through the subarachnoid space and attach to the pia mater.
The majority of the CSF is formed in the choroid plexus and flows through the brain along a distinct pathway: moving through the cerebral ventricular system, into the subarachnoid space surrounding the brain, then draining into the systemic blood column via arachnoid granulations of the dural sinuses or to peripheral lymphatics along cranial ...
It has been proposed that a positive biofeedback loop may exist, where raised ICP (intracranial pressure) causes venous narrowing in the transverse sinuses, resulting in venous hypertension (raised venous pressure), decreased CSF resorption via arachnoid granulation and further rise in ICP. [16]
Second, the breakdown products from the blood clot may generate an inflammatory response that damages the arachnoid granulations, inhibiting the regular re-absorption of CSF and resulting in permanent communicating hydrocephalus. [2] [14]
The meningeal layer lays over the spinal arachnoid mater. [2] Between the vertebrae and the dural sheath is the spinal epidural space . Unlike the cranial epidural space, the spinal epidural space contains adipose tissue , the internal vertebral venous plexuses and the spinal nerve roots. [ 1 ]
The brain and spinal cord are covered by the meninges, the three protective membranes of the tough dura mater, the arachnoid mater and the pia mater. The cerebrospinal fluid (CSF) within the skull and spine provides further protection and also buoyancy, and is found in the subarachnoid space between the pia mater and the arachnoid mater.
On either side of it are several depressions for the arachnoid granulations, and at its back part, the openings of the parietal foramina when these are present. It is crossed in front by the coronal suture and behind by the lambdoid suture, while the sagittal suture lies in the medial plane between the parietal bones.