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Researchers observed immune-related side effects in 73 patients, with severe (grade 3 or 4) events occurring in 5 patients. None of the patients discontinued treatment due to these adverse events.
Immunotherapy or biological therapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies .
[4] [9] Adverse effects may be class-dependent, and so switching to a biologic of another class may ameliorate those effects. [ 7 ] Potential serious adverse effects include allergic reactions , liver damage, cancer, and serious infections including tuberculosis , pneumonia , staph infection , and fungal infection .
Those risks may or may not be so modifiable for ... drugs that are better tolerated with decreased side effects for patients, ... a type of immunotherapy for a rare cancer called synovial sarcoma ...
Overall, only about 1 in 20 patients have severe side effects from immunotherapies, with skin rashes and flu-like fatigue the most common relatively minor factors. The 'C' word: Cure
Common side effects include fatigue, musculoskeletal pain, diarrhea, nausea, infusion-related reactions, rash, decreased appetite and swelling of the limbs (peripheral edema). [ 7 ] Avelumab targets the protein programmed death-ligand 1 (PD-L1).
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