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Hydrocortisone is the name for the hormone cortisol when supplied as a medication. [14] It is a corticosteroid and works as an anti-inflammatory and by immune suppression . [ 1 ] Uses include conditions such as adrenocortical insufficiency , adrenogenital syndrome , high blood calcium , thyroiditis , rheumatoid arthritis , dermatitis , asthma ...
In addition, hydrocortisone has a relatively wide therapeutic window, [14] implying that toxicity is less likely to occur. Topical hydrocortisone contributes to inflammatory-reducing activity in various ways. [27] Firstly, hydrocortisone can bind to glucocorticoid receptors in the cytoplasm, causing alterations in the conformation of the receptors.
The Surviving Sepsis Campaign guidelines advocate intravenous hydrocortisone only in adults with septic shock and refractory hypotension. [4] The exact definition of this condition, the best ways to test for corticoid insufficiency in critically ill patients, and the therapeutic use of (usually low doses) of corticosteroids remains a subject of ...
Therapeutic doses may cause a feeling of artificial well-being ("steroid euphoria"). [22] The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm; if given at night, the feeling of being ...
If an inappropriate formulation is administered, the therapeutic effect of the treatment may be delayed and rendered insufficient. [2] The condition will even be worsened in some cases. For instance, usage of a topical glucocorticoid gel on fissured hand eczema intensifies the pain as well as stinging because of the alcohol present in the gel.
Hydrocortisone sodium succinate, sold under the brand name Solu-Cortef among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. [ 3 ] Hydrocortisone sodium succinate was approved for medical use in the United States in 1955.
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