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Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the brain, and absorbed in the arachnoid granulations. In humans, there is about 125 mL of CSF at any one time ...
The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection.
The name "colony-stimulating factors" comes from the method by which they were discovered. Hematopoietic stem cells were cultured (see cell culture) on a so-called semisolid matrix, which prevents cells from moving around, so that, if a single cell starts proliferating, all of the cells derived from it will remain clustered around the spot in the matrix where the first cell was originally located.
Colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34) are both CSF1R ligands. Both ligands regulate myeloid cell survival, proliferation, and differentiation, but CSF-1 and IL-34 differ in their structure, distribution in the body, and the specific cellular signaling cascades triggered upon binding to CSF1R. [8]
The cerebrospinal fluid (CSF) within the skull and spine provides further protection and also buoyancy, and is found in the subarachnoid space between the pia mater and the arachnoid mater. [citation needed] The CSF that is produced in the ventricular system is also necessary for chemical stability, and the provision of nutrients needed by the ...
Former firebrand Rep. Matt Gaetz acknowledged that he was something of a party animal and womanizer during his 30's when he was a lawmaker, but vehemently denied accusations that he had sexual ...
Macrophage colony-stimulating factor, "CSF-1" Granulocyte-macrophage colony-stimulating factor, "CSF-2" Granulocyte colony-stimulating factor, "CSF-3" Cancer slope factor, estimate the risk of cancer; Classical swine fever, contagious disease of pigs; Contrast sensitivity function, relationship of contrast threshold vs angular frequency for an ...
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