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The prostate is a exocrine gland of the male reproductive system. In adults, it is about the size of a walnut, [2] and has an average weight of about 11 grams (0.39 oz), usually ranging between 7 and 16 grams (0.25–0.56 oz). [3] The prostate is located in the pelvis. It sits below the urinary bladder and surrounds the urethra.
It often enlarges as men age, ... 25% of patients with elevated PSAs are found to have prostate cancer on biopsy when 4 mg/dl is used as the cut-off for normal. In addition, some men with prostate ...
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. [1] Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control. [1]
In a study of young adults in Greece (aged 21–50, mean age 40.9 years), the prevalence was found to be 7.35%. [4] While among urologic patients in South Korea (aged 29–89, mean age 61.9 years), the prevalence was 40.7%. [5] The prevalence is notably higher in patients with benign prostatic hyperplasia, ranging from 68.8% to 70%. [3]
They are more likely to get prostate cancer and more than twice as likely to die from prostate cancer than other men. The average age of diagnosis is 66 years old.
The most common cause of urinary retention is BPH. This disorder starts around age 50 and symptoms may appear after 10–15 years. BPH is a progressive disorder and narrows the neck of the bladder leading to urinary retention. By the age of 70, almost 10 percent of males have some degree of BPH and 33% have it by the eighth decade of life.
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5α-Dihydrotestosterone (DHT) was 2.4 times more potent than testosterone at maintaining normal prostate weight and duct lumen mass (this is a measure of epithelial cell function stimulation). Whereas DHT was equally potent as testosterone at preventing prostate cell death after castration. [24]
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