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Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, [ 1 ] [ 2 ] activin enhances FSH biosynthesis and secretion , and participates in the regulation of the menstrual cycle .
Inhibin can bind specifically to testicular interstitial cells throughout development and may be an important regulator of Leydig cell testosterone production or interstitial cell function. [8] The inhibin beta B subunit joins the α subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell ...
16325 Ensembl ENSG00000175189 ENSMUSG00000025405 UniProt P55103 P55104 RefSeq (mRNA) NM_005538 NM_010565 RefSeq (protein) NP_005529 NP_034695 Location (UCSC) Chr 12: 57.43 – 57.45 Mb Chr 10: 127.19 – 127.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene. This gene encodes the beta C chain of inhibin, a ...
Inhibin, beta A, also known as INHBA, is a protein which in humans is encoded by the INHBA gene. [5] INHBA is a subunit of both activin and inhibin , two closely related glycoproteins with opposing biological effects.
They are responsible for the differentiation of spermatids, the maintenance of the blood-testis barrier, and the secretion of inhibin, androgen-binding protein and Müllerian-inhibiting factor. [citation needed] The organ of Corti in the inner ear and taste buds also contain sustentacular cells. [citation needed]
3623 16322 Ensembl ENSG00000123999 ENSMUSG00000032968 UniProt P05111 Q04997 RefSeq (mRNA) NM_002191 NM_010564 NM_001329843 RefSeq (protein) NP_002182 NP_001316772 NP_034694 Location (UCSC) Chr 2: 219.57 – 219.58 Mb Chr 1: 75.48 – 75.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene ...
Because its main function is to nourish developing sperm cells through the stages of spermatogenesis, the Sertoli cell has also been called the "mother" or "nurse" cell. [10] Sertoli cells also act as phagocytes, consuming the residual cytoplasm during spermatogenesis. Translocation of cells from the basal lamina to the lumen of the ...
HPG regulation in males, with the inhibin/activin system playing a similar role on GnRH-producing cells. The hypothalamus is located in the brain and secretes GnRH. [1] GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the secretory cells of the adenohypophysis. [2]