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Members of the Argonaute (Ago) protein family are central to RISC function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3' end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5 ...
Function Distribution Ref. Antisense RNA: aRNA, asRNA: Transcriptional attenuation / mRNA degradation / mRNA stabilisation / Translation block: All organisms [11] [12] Cis-natural antisense transcript: cis-NAT Gene regulation: CRISPR RNA: crRNA: Resistance to parasites, by targeting their DNA: Bacteria and archaea [13] Long noncoding RNA: lncRNA
It is concluded that the miRNA has an important function in the central pacemaker of the Drosophila circadian rhythm clock. To be more precise Bantam miRNA has an important relation with the clock component clk, thus making it an important factor of study regarding its role in Drosophila behavior.
miR-92 is part of a large precursor sequence that forms a stem loop once transcribed into RNA. This long precursor sequence is a component of the mir-17-92 cluster which contains 5 additional mir precursor sequences: mir-17, mir-18a, mir-19a, mir-20a and mir19b-1. [4]
n/a Ensembl ENSG00000284190 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 17: 59.84 – 59.84 Mb n/a PubMed search n/a Wikidata View/Edit Human microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene. MIRN21 was one of the first mammalian microRNAs identified. The mature miR-21 sequence is strongly ...
[3] [4] Mirtrons arise from the spliced-out introns and are known to function in gene expression. Mirtrons were first identified in Drosophila melanogaster and Caenorhabditis elegans . [ 5 ] [ 6 ] The number of mirtrons identified to date are 14, 9, and 19 in D. melanogaster, C. elegans and mammals respectively. [ 7 ]
The miR-17-92 cluster containing miR-19 miRNA family is also involved into control endothelial cell functions and neo-vascularization. MiRNA cluster (miR-17, miR-18, miR-19 and miR-20) increased during the induction of endothelial cell differentiation in embryonic stem cells (tested on murine) or induce pluripotent stem cells.
The current evidence points toward P-bodies as being scaffolding centers of miRNA function, especially due to the evidence that a knock down of GW182 disrupts P-body formation. However, there remain many unanswered questions about P-bodies and their relationship to miRNA activity.