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  2. Primary biliary cholangitis - Wikipedia

    en.wikipedia.org/wiki/Primary_biliary_cholangitis

    Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [ 1 ] [ 2 ] [ 3 ] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis .

  3. Anti-mitochondrial antibody - Wikipedia

    en.wikipedia.org/wiki/Anti-mitochondrial_antibody

    Anti-mitochondrial antibodies (AMA) are autoantibodies, consisting of immunoglobulins formed against mitochondria, [1] primarily the mitochondria in cells of the liver.. The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary biliary cholangitis (PBC; previously known as primary biliary cirrhosis).

  4. Cholestatic pruritus - Wikipedia

    en.wikipedia.org/wiki/Cholestatic_pruritus

    Cholestatic pruritus is the sensation of itch due to nearly any liver disease, but the most commonly associated entities are primary biliary cholangitis, primary sclerosing cholangitis, obstructive choledocholithiasis, carcinoma of the bile duct, cholestasis (also see drug-induced pruritus), and chronic hepatitis C viral infection and other forms of viral hepatitis.

  5. Primary sclerosing cholangitis - Wikipedia

    en.wikipedia.org/wiki/Primary_sclerosing_cholangitis

    The differential diagnosis can include primary biliary cholangitis (formerly referred to as primary biliary cirrhosis), drug-induced cholestasis, cholangiocarcinoma, IgG4-related disease, post-liver transplantation nonanastomotic biliary strictures, [23] and HIV-associated cholangiopathy. [24]

  6. Human betaretrovirus - Wikipedia

    en.wikipedia.org/wiki/Human_betaretrovirus

    Human betaretrovirus (HBRV) has been extensively studied in its connection to the autoimmune liver disease, primary biliary cholangitis (PBC). [3] Various research approaches have been employed, including in vitro HBRV co-cultivation studies using biliary epithelium, the use of autoimmune biliary disease mouse models with MMTV infection and the ...

  7. Vanishing bile duct syndrome - Wikipedia

    en.wikipedia.org/wiki/Vanishing_Bile_Duct_Syndrome

    This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed

  8. Cholestasis - Wikipedia

    en.wikipedia.org/wiki/Cholestasis

    Chronic cholestasis occurs in primary biliary cholangitis (PBC). PBC is a progressive autoimmune liver disease in which small intrahepatic bile ducts are selectively destroyed, leading to cholestasis, biliary fibrosis, cirrhosis, and eventually liver failure that requires transplantation.

  9. Child–Pugh score - Wikipedia

    en.wikipedia.org/wiki/Child–Pugh_score

    In primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), some use a modified Child–Pugh score where the bilirubin references are changed to reflect the fact that these diseases feature high conjugated bilirubin levels. The upper limit for 1 point is 68 μmol/L (4 mg/dL) and the upper limit for 2 points is 170 μmol/L (10 ...