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Normally, joint cartilages have proteoglycan complexes, which are proteins with side chains made of glycosaminoglycans such as keratan sulfate and chondroitin sulfate attached to strands of hyaluronic acid. The glycosaminoglycan side chains are polyanionic, which causes adjacent side chains to push each other away and create a "bottle brush ...
One group of common alternative treatments are nutraceutical supplements. The most popular of these are joint supplements such as glucosamine, chondroitin, MSM, and hyaluronic acid. Related to joint supplements are various treatments for pain, viewed as alternatives to the common mainstream pain-reducing medications phenylbutazone, and banamine ...
A number of studies have measured the bioavailability of glucosamine after oral administration to horses. When given as a single oral dose (9 g) with or without chondroitin sulfate (3 g) to ten horses, glucosamine (hydrochloride) was detected in the blood with a maximum level of 10.6 ± 6.9 μg/mL at two hours after dosing. [47]
A significant amount of research has been performed on glycosaminoglycans, especially glucosamine and chondroitin, for the treatment of arthritis.These compounds are commonly marketed as nutritional supplements and numerous 'soft therapeutic claims' are made about their health benefits - especially in aging populations. [1]
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A chondroprotective compound is a specific compound or chemical that delays progressive joint space narrowing characteristic of arthritis and improves the biomechanics of articular joints by protecting chondrocytes. [1] These agents perform various functions, such as: Stimulating chondrocyte synthesis of collagen and proteoglycans
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