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In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
The median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration.
Absolute lethal concentration, LC 100; Absolute lethal dose, LD 100 The most referenced value in the chemical industry is the median lethal dose, or LD50. This is the concentration of substance which resulted in the death of 50% of test subjects (typically mice or rats) in the laboratory.
As little as 10 mL of pure methanol when drunk is metabolized into formic acid, which can cause permanent blindness by destruction of the optic nerve. 15 mL is potentially fatal, [1] although the median lethal dose is typically 100 mL (3.4 fl oz) (i.e. 1–2 mL/kg body weight of pure methanol). [4] Reference dose for methanol is 0.5 mg/kg/day. [9]
The oral median lethal dose was 115 mg/kg. [1] The same study reported that ten minutes after an oral dose of 160 mg/kg, the animals experienced breathing problems that eventually led to death. Acute Rat studies (mg/kg) - LDLo test, via oral route: 115 - LD50 test, intraperitoneal route: 11.6 - LD50 test, intravenous: 8.2
LT50 is the median Lethal Time (time until death) [1] [2] after exposure of an organism to a toxic substance or stressful condition. LT50 is commonly used in toxicology studies to quantify amount of a stressor necessary to kill an organism. LT50 can be used in conjunction with EC50 (median Exposure Concentration) for even more precise ...
Prescriptions for lethal doses of medication in Oregon increased by nearly 30% in 2023, the same year an amendment to the state's Death with Dignity Act removed the in-state residency requirement ...
For an adult human, exposure to 2 Gy from an unfocused radiation source such as an excursion will cause radiation sickness but is not definitely lethal; about 4.5 to 5 Gy is the LD 50, or median lethal dose; 8 Gy is the LD 99. [6] [7] [8] Kelley had received more than 7 times the LD 50.