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The lowest lethal dose (LD Lo) is the least amount of drug that can produce death in a given animal species under controlled conditions. [ 6 ] [ 7 ] The dosage is given per unit of bodyweight (typically stated in milligrams per kilogram ) of a substance known to have resulted in fatality in a particular species.
In toxicology, the median lethal dose, LD 50 (abbreviation for "lethal dose, 50%"), LC 50 (lethal concentration, 50%) or LCt 50 is a toxic unit that measures the lethal dose of a given substance. [1] The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration.
In toxicology, the lowest published toxic dose (Toxic Dose Low, TD Lo) is the lowest dosage per unit of bodyweight (typically stated in milligrams per kilogram) of a substance known to have produced signs of toxicity in a particular animal species. [1]
Absolute lethal concentration, LC 100; Absolute lethal dose, LD 100 The most referenced value in the chemical industry is the median lethal dose, or LD50. This is the concentration of substance which resulted in the death of 50% of test subjects (typically mice or rats) in the laboratory.
For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.
The lowest published lethal dose (LDLo) for mice is 1 mg/kg orally and 0.100 mg/kg intraperitoneally. The lowest published toxic dose (TDLo) for mice is 0.0549 mg/kg subcutaneously. LD50 value for rats is 0.064 mg/kg intravenously.
The lowest lethal dose recorded in humans is 171 ug/kg. [20] There is no information regarding the long-term or carcinogenic effects of exposure to demeton in humans. In vitro mutagenicity tests have shown that demeton has a significant genotoxic potential. However, disulfoton, of which demeton-S is a metabolite, has not been observed to have ...
The median lethal dose (LD 50) of a venom is the dose required to kill half the members of a tested population after a specified test duration. A lower LD 50 number indicates increased toxicity. There are four methods in which the LD 50 test is measured: