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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. [1] [2] It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS.
Schematic of the Emulate liver-chip [4] Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
A prominent example of an intestine-on-a-chip system relying on architectural cues is the homeostatic mini-intestines by Nikolaev et al. [24] They use microfabricated intestine-on-a-chip devices with a hydrogel chamber. The collagen-Matrigel-mix hydrogel is laser-ablated to generate a microchannel for a tubular intestinal lumen with crypt ...
Organ-on-chips work by providing a 3D model that imitates the natural extracellular matrix, allowing them to display realistic responses to drugs. [29] Thus far, research has been focused on developing liver-on-a-chip and heart-on-a-chip, but there exists the potential to develop an entire body-on-a-chip model. [29]
Benartzi 2004) and organ donation (Eric J. Johnson and Daniel Goldstein 2003). Inspired by dramatic results like these, we made healthy options the implicit default in our experimental condition intended to increase healthy choices. Overview of the Current Study The study was designed to assess the effects of informational vs. asymmetrically
3. Keebler Fudge Magic Middles. Neither the chocolate fudge cream inside a shortbread cookie nor versions with peanut butter or chocolate chip crusts survived.
Following the lung-on-a-chip, the team built a kidney-on-a-chip and an intestine-on-a-chip. [14] In 2014, Emulate spun out to make organ chips commercially available for other scientists to use for disease modeling and drug testing, [15] [16] [17] including those at Johnson & Johnson, Merck, Takeda, Roche, and Cedars-Sinai Medical Center. [18]