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Medtronic (NYS: MDT) announced Wednesday that it is offering a $2.5 million grant to Yale researchers who will independently review the safety of the company's controversial Infuse bone graft product.
Bone grafting is a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly. Some small or acute fractures can be cured without bone grafting, but the risk is greater for large fractures like compound fractures.
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. [1] Professor Marshall Urist and Professor Hari Reddi discovered their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body.
12156 Ensembl ENSG00000125845 ENSMUSG00000027358 UniProt P12643 P21274 RefSeq (mRNA) NM_001200 NM_007553 RefSeq (protein) NP_001191 NP_031579 Location (UCSC) Chr 20: 6.77 – 6.78 Mb Chr 2: 133.39 – 133.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Function BMP-2 like other bone morphogenetic ...
In medicine, the Ilizarov apparatus is a type of external fixation apparatus used in orthopedic surgery to lengthen or to reshape the damaged bones of an arm or a leg; used as a limb-sparing technique for treating complex fractures and open bone fractures; and used to treat an infected non-union of bones, which cannot be surgically resolved.
Osteoplasty is the branch of surgery concerned with bone repair or bone grafting. [1] It is the surgical alteration or reshaping of bone. [2] It may be used to relieve pain associated with metastatic bone disease. [3] [unreliable medical source?] Percutaneous osteoplasty [4] involves the use of bone cement to reduce pain and improve mobility. [5]
Xenotransplantation is a cross-species tissue transplantation from animal to human. [10] [11] The development of blood vessel anastomosis opened the door for xenotransplantation during the 20th century, which led to numerous attempts in organ transplantations with tissues from nonhuman primates (NHPs).
In orthopaedic medicine, a bone graft can be sourced from a patient's own bone in order to fill space and produce an osteogenic response in a bone defect. However, due to the donor-site morbidity associated with autograft, other methods such as bone allograft and bone morphogenetic proteins and synthetic graft materials are often used as alternatives.