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Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main differences relative to pure diphenhydramine are a lower potency due to being combined with 8-chlorotheophylline (by weight, dimenhydrinate is between 53% and 55.5% diphenhydramine) [10] and the fact that the stimulant properties of 8-chlorotheophylline help reduce the side ...
Dimenhydrinate; Alkylamines: The isomerism is a significant factor in the activity of the agents in this group. E-triprolidine, for example, is 1000-fold more potent than Z-triprolidine. This difference relates to the positioning and fit of the molecules in the histamine H 1-receptor binding site. [15]
Antihistamine drugs can have undesirable side-effects, the most notable one being drowsiness in the case of oral antihistamine tablets. First-generation antihistamine drugs such as diphenhydramine cause drowsiness, while second- and third-generation antihistamines such as fexofenadine and loratadine are less likely to. [52] [53]
Potentiates CNS sedatives, [3] chronic use might cause a reversible dry skin condition. [18] Khat: qat Catha edulis: Chronic liver dysfunction [3] [19] Kratom: Mitragyna speciosa: Hepatotoxicity [20] [19] Liquorice root Glycyrrhiza glabra: Hypokalemia, hypertension, arrhythmias, edema [5] Lobelia: asthma weed, pukeweed, vomit wort Lobelia inflata
The evidence does not report how antihistamines affect women differently than men. [1] Different studies have reported on antihistamine use in children, with various studies finding evidence that certain antihistamines could be used by children 2 years of age, and other drugs being safer for younger or older children.
8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. [1] Its main use is in combination (salt) with diphenhydramine in the antiemetic dimenhydrinate (Dramamine).
During the pandemic era, stimulus checks were a lifeline for many Americans. Now, if Elon Musk and President Donald Trump make some moves, Americans could be getting another round of payments in ...
Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.