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Treatment Occupational therapy, weight decrease (management) [ 1 ] Polyneuropathy (from Greek poly- 'many' neuro- 'nerve' and -pathy 'sickness') is damage or disease affecting peripheral nerves ( peripheral neuropathy ) in roughly the same areas on both sides of the body, featuring weakness , numbness , and burning pain. [ 1 ]
The gabapentinoid drugs do not bind significantly to other known drug receptors and so the α 2 δ VGCC subunit has been called the gabapentin receptor. [ 15 ] [ 4 ] Recently, the same α 2 δ-1 protein has been found closely associated not with VGCCs but with other proteins such as presynaptic NMDA-type glutamate receptors , cell adhesion ...
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
Carbamazepine is most commonly prescribed to treat trigeminal neuralgia due to clinical experience and early clinical trials showing strong efficacy. Gabapentin may reduce symptoms associated with neuropathic pain or fibromyalgia in some people. [26] There is no predictor test to determine if it will be effective for a particular person.
In 2022, it was the tenth most commonly prescribed medication in the United States, with more than 40 million prescriptions. [ 18 ] [ 19 ] During the 1990s, Parke-Davis , a subsidiary of Pfizer , used a number of illegal techniques to encourage physicians in the United States to prescribe gabapentin for unapproved uses. [ 20 ]
Diabetes mellitus neuropathy (the most common in the U.S. today, resulting in destruction of foot and ankle joints), with Charcot joints in 1/600–700 diabetics; related to long-term high blood glucose levels. Alcoholic neuropathy; Cerebral palsy; Leprosy; Syphilis (tabes dorsalis), caused by the organism Treponema pallidum; Spinal cord injury ...
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