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A 2020 Cochrane review found no evidence that melatonin helped sleep problems in people with moderate to severe dementia due to Alzheimer's disease. [36] A 2019 review found that while melatonin may improve sleep in minimal cognitive impairment, after the onset of Alzheimer's disease it has little to no effect. [37]
The etymology of melatonin stems from its skin-lightening properties. As detailed in their publication in the Journal of the American Chemical Society, [67] Lerner and his colleagues proposed the name melatonin, derived from the Greek words melas, meaning 'black' or 'dark', and tonos, meaning 'labour', [68] 'colour' [69] or 'suppress'. [70]
[1] 6-Hydroxymelatonin is produced as a result of the enzymatic conversion of melatonin through hydroxylation. [2] Similar to melatonin, 6-OHM is a full agonist of the MT 1 and MT 2 receptors. [3] [4] It is also an antioxidant and neuroprotective, and is even more potent in this regard relative to melatonin. [5] [6]
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